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TELOMERE 26

• CAN SHORTENED TELOMERES BE REVERSED?
  There is scientific evidence that telomeres can be lengthened. An enzyme called telomerase can slow or even reverse the telomere shortening that happens as we age. The amount of telomerase in our bodies declines as we age. Telomerase maintains and may even lengthen Telomeres.
• WHAT IS A TELOMERE?
  Telomeres are structures made from DNA sequences and proteins found at the ends of chromosomes. They cap and protect the end of a chromosome. They also separate one chromosome from another to prevent fusion and genomic instability.
• WHY DO TELOMERES SHORTEN?
  When the telomere becomes too short (genetically pre-determined, age, stress, diet, lifestyle-related), the chromosome reaches a ‘critical length’ and can no longer be replicated. This ‘critical length’ triggers the cell to die by a process called apoptosis, also known as programmed cell death. Shorter telomeres have a negative effect on our health in general.
• SHORTER TELOMERES AND CANCER, INFECTIOUS DISEASE OR HEART DISEASE?
  Shorter telomeres have also been implicated in genomic instability and oncogenesis. Genomic instability is the increased tendency for DNA mutations (changes) and other genetic changes to occur during cell division. Genomic instability is caused by defects in certain processes that control the way cells divide. It occurs in many types of cancer. These defects may include mutations in certain genes involved in repairing damaged DNA or mistakes that do not get corrected when DNA is copied in a cell. They may also include defects such as broken, missing, rearranged, or extra chromosomes.
• Older people with shorter telomeres have a three and eight times increased risk of death from heart or infectious diseases, respectively.