KEY INGREDIENTS

• Silibin Pytosomes 1 %: boosts ECM components structure ( Collagen 3, Collagen 1, and HA.
  Reduces wrinkle thickness on crow' s feet by x 2 , and forehead wrinkles by 2 . 3 . Reduces redness, and extreme tolerability. Increases hydration significantly.
• Niacinamide (vitamin B 3): addresses cellular respiration, and lipid synthesis, along with offering anti-oxidant properties. Helps improve barrier function, inhibit pigmentation, as well as smooth the appearance of fine lines. Promotes overall complexion improvement.
• Squalane: lipid sourced from olives, which enhances the skin’s natural protective barrier. Squalene deeply nourishes and replenishes dry skin.
• Bisabalol: (L- alpha)- Distilled from the Candela Tree, component of Chamomile Essential oils, possesses functions that help to soothe skin sensitivities.
• Shea butter: Nourishing.
• Neodermyl: re-energises cells by triggering collagen 1, 3 and elastin production to reduce the appearance of deep wrinkles, improving skin' s firmness and elasticity. The ‘ needle- free’ collagen and elastin filler.

DIRECTIONS FOR USE

• Apply at night only
• It is essential to apply DERMACLINICAL SPF 50, daily

IDEAL FOR

• Dry skins with pigmentation, ageing and scarring, sensitive skins, for skins that cannot tolerate retinal
• Can be used in Pregnancy or when taking Accutane
• SAFE TO USE for DRY AND SENSITIVE SKINS

MTX REFORM SERUM -
PHYTO RETINOL

SOME OF THE MOST IMPORTANT CONSTITUENTS OF THE ECM (EXTRACELLULAR MATRIX) IN THE DERMIS, ARE COLLAGEN AND GLYCOSAMINOGLYCANS (LIKE HYALURONIC ACID).

IN PARTICULAR, COLLAGEN 1 AND 3 ARE THE MOST ABUNDANT. COLLAGEN 3 IS ESSENTIAL FOR THE FINE FIBRILL DEVELOPMENT IN COLLAGEN FIBRES. COLLAGEN 3 PLAYS A KEY ROLE IN THE EPIDERMAL/DERMAL JUNCTION.

FACTS ABOUT MTX REFORM SERUM CLINICAL RESULTS (AFTER 8 WEEKS (56 DAYS) ON 60 VOLUNTEERS) WITH 0.8% CONCENTRATION:

• 23% more Collagen 3 production compared to Bakuchiol and 16% more when compared with Retinol 0.2%.
• 14% increase in Collagen 1 compared to Bakuchiol.
• 36% more Hyaluronic Acid production compared to Bakuchiol. Equivalent to Retinol.
• Reduces the thickness of wrinkles by 2.3 times more than placebo.
• 24.3% decrease in the number of wrinkles on the forehead vs placebo. 21.2% decrease vs Bakuchiol.
• 22.9% less redness vs the Retinol test.
• 9.1% increased hydration vs Retinol.
• 0% irritation vs 42.9% retinol stats.
• zero side effects.

WE ARE USING 1% CONCENTRATION IN THIS FORMULA.

RARy IS THE MAIN RECEPTOR ACCOUNTING FOR 87% OF ALL RAR RECEPTORS. THEY ARE FOUND IN KERATINOCYTES AND FIBROBLASTS - EQUALLY.
It is the mechanism responsible for the irritation induced by retinoids.

RARa IS MORE ABUNDANT IN FIBROBLASTS THAN KERATINOCYTES
More are found in mature skin than in young skin. Linked to suppression of RARy signals (irritation), so it does not increase irritation.

FACTS ABOUT RARy ACTIVATION:

Retinol highly activates the RARy receptor. Bakuchiol slightly activates the RARy receptor.
MTX Reform Serum does not activate the RARy receptor at all.

FACTS ABOUT UV ABSORPTION:

Retinol stimulates photosensitivity and has a keratolytic effect, reducing skin protection against UV rays. Bakuchiol has no sun sensitivity concerns.
MTX Reform Serum absorbs both UVA and UVB - SO IS NOT LIGHT-SENSITIVE (we are still recommending it at night, as this will replace the regular ‘retinol’ position.